Professor Susan Lindsay
DGEMap Coordinator
Susan Lindsay's major research interest is in human development.
The basis of this work was the establishment with Prof Strachan (Institute of Human Genetics, Newcastle University), Prof Robson (Dept. of Fetal Medicine, Newcastle University) and Prof Andy Copp (Institute of Child Health, UCL, London), of an extensive, national collection of human embryonic and fetal tissue (MRC-Wellcome Trust Human Developmental Biology Resource).
DGEMap arises from this and aims at identifying and evaluating the facilities and resources needed for large-scale gene expression studies and analyses during early human development. These would form the framework for a new research infrastructure. For further information on DGEMap, please visit the following page.
Some of Prof Lindsay's projects are focussed on the early development of the human brain, including expression analyses of key developmental and disease-related genes and, in collaboration with colleagues in Edinburgh and Murcia, the development of a computer-based atlas of the developing human brain. The atlas will consist of anatomically annotated 3-dimensional models and a gene expression database.
In collaboration with Prof Janet Eyre and Dr Gavin Clowry in Child Health (Newcastle University), Susan Lindsay also examines the development of a specific system in the central nervous system over a more extensive period of development. They are interested in the development and function of the motor system, both in normal conditions and in relation to cerebral palsy.
Selected Publications
- Lindsay S, Subrot Sarma, Margaret Martínez-de-la-Torre, Janet Kerwin, Mark Scott, Jose Luis Ferran, Richard Baldock and Luis Puelles. Anatomical and gene expression mapping of the ventral pallium in a 3-dimensional model of developing human brain. Neuroscience 2005, 136, 625-632
- Lindsay S and Copp AJ. Title MRC-Wellcome Trust Human Developmental Biology Resource: enabling studies of human developmental gene expression. Trends in Genetics 2005, 21, 586-590
- J Kerwin, M Scott, J Sharpe, L Puelles, SC Robson, M Martínez-de-la-Torre, JL Ferran, G Feng, R Baldock, T Strachan, D Davidson and S Lindsay. 3 dimensional modelling of early human brain development using optical projection tomography. BMC Neuroscience 2004, 5, 27
- Braybrook C, Lisgo S, Doudney K, Henderson D, Marcano AC, Strachan T, Patton MA, Villard L, Moore GE, Stanier P, Lindsay S. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Human Molecular Genetics 2002, 11, 2793-2804
- D. M. Hagan, A. J. Ross, T. Strachan, S. A. Lynch, V. Ruiz-Perez, Y. M. Wang, P. Scambler, E. Custard, W. Reardon, S. Hassan, M. Muenke, P. Nixon, C. Papapetrou, R. M. Winter, Y. Edwards, K. Morrison, M. Barrow, M. P. Cordier-Alex, P. Correia, P. A. Galvin-Parton, S. Gaskill, K. J. Gaskin, S. Garcia-Minaur, R. Gereige, R. Hayward, T. Homfray, C. McKeown, V. Murday, H. Plauchu, N. Shannon, L. Spitz and S. Lindsay. Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. American Journal of Human Genetics 2000, 66, 1504-1515
- M. Clement-Jones, S. Schiller, E. Rao, R. J. Blaschke, A. Zuniga, R. Zeller, S. C. Robson, G. Binder, I. Glass, T. Strachan, S. Lindsay and G. A. Rappold. The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome. Human Molecular Genetics 2000, 9, 695-702
Email : s.lindsay@ncl.ac.uk